It is highly recommended to have One EndNote Library, and to create Groups and Group Sets to organize your references.
There are different types of groups in EndNote. Some of these groups can be manually created such as
Please Note that you can create up to 5,000 group sets in your EndNote library.
To delete or rename a group, right click on the name of the group and select Delete Group.
Please note that the group name will be deleted, however the references will remain in your EndNote library.
I. Create Group Sets
To avoid ending up with a large number of groups start by creating Group Sets.
II. Create Groups
These groups allow you to add references individually.
Smart groups will automatically add references to your group if they match a particular search strategy.
Note: Each time you add a reference to the library, EndNote updates the smart group automatically.
Smart groups are dynamically updated by applying search criteria to each reference as it is added or updated.